Hybrid strains are cannabis plants that are a mix of both indica and sativa varieties. These strains are bred to combine the effects of both, offering a balance that can be tailored toward the user's preference. For example, a hybrid might have the relaxing body effects of an indica and the uplifting, cerebral high of a sativa. This blend makes hybrids versatile and popular for those seeking specific effects.​​

In terms of use, hybrids can be either sativa-dominant, indica-dominant, or balanced, depending on the traits of the parent strains. A sativa-dominant hybrid might provide more energy and creativity with a bit of relaxation, while an indica-dominant hybrid might be more calming but still maintain some mental clarity.